Subacute toxicity reports in dogs for 4 weeks at 480 mg/kg day-to-day confirmed no certain adjustments; at 960 mg/kg, two out of 8 died with proof of circulatory collapse. This extensive margin of protection is important when compared with chlordiazepoxide HCl, which showed nonspecific modifications in six canine at 80 mg/kg.Flumazenil Working with